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. Author manuscript; available in PMC: 2015 Feb 1.
Published in final edited form as: Trends Biochem Sci. 2013 Dec 6;39(2):53–60. doi: 10.1016/j.tibs.2013.11.003

Figure 1. Protein degradation by ATP-dependent proteases.

Figure 1

A protein substrate is specifically recognized by the unfoldase and engaged by residues located in the central pore. Downstream ATP-dependent steps lead to the unfolding of the substrate and the subsequent translocation of the unfolded polypeptide through the central pore of the unfoldase into the degradation chamber of the peptidase for proteolysis.