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. Author manuscript; available in PMC: 2015 Feb 1.
Published in final edited form as: Neuropeptides. 2013 Nov 15;48(1):47–51. doi: 10.1016/j.npep.2013.11.001

Figure 1.

Figure 1

Ethanol consumed (g/kg) among MC3R−/− and MC3R+/+ mice during the first hour (A), and total four hours (B) of the binge-like ethanol consumption, as well as BEC (mg/dl) measured immediately at the end of the 4-hour test (C). During the first hour, MC3R−/− mice displayed a reduction in binge-like ethanol drinking at all doses tested. Alternatively, significant reductions in drinking were only observed following treatment with the highest dose (1.0 μg) of MTII in MC3+/+ mice. Similarly, at the end of the 4-hour test, only the highest dose of MTII caused a reduction in binge-like ethanol drinking in MC3R−/− mice. No significant effect of MTII was observed on BEC regardless of genotype. Data are presented as mean ± SEM. * signifies p < .05 relative to vehicle within that genotype.