. Author manuscript; available in PMC: 2015 Feb 1.

Published in final edited form as: Pharm Res. 2013 Sep 10;31(2):347–359. doi: 10.1007/s11095-013-1164-7

TABLE 1.

A→B and B→A receiver concentrations at 90 min and efflux ratios for atorvastatin in MDCK-MDR1 cells with or without CsA. Three sets of experiments are reported.

Drug	f_um	Cell	C₀	C_r,AB	C_r,BA	ER
			μM
Atorvastatin1	0.52	MDCK-MDR1	5	0.004	0.47	38
		MDCK-MDR1 + CsA	5	0.01	0.02	0.4
Atorvastatin2	0.52	MDCK-MDR1	0.5	0.001	0.05	12
		MDCK-MDR1 + CsA	0.5	0.005	0.01	0.9
Atorvastatin3	0.52	MDCK-MDR1	5	0.01	0.75	17
		MDCK-MDR1 + CsA	5	0.07	0.16	0.7

Notations are defined as follows: f_um: fraction of drug unbound in microsomes; C₀: drug concentration at time zero; C_r,AB: concentration in the receiver compartment upon apical drug exposure; C_r,BA: concentration in the receiver compartment upon basolateral drug exposure; ER: efflux ratio