. Author manuscript; available in PMC: 2015 Feb 1.

Published in final edited form as: Pharm Res. 2013 Sep 10;31(2):347–359. doi: 10.1007/s11095-013-1164-7

TABLE 4.

Estimates of clearances, lag time, and intracellular concentrations obtained with the 5C model. Parameter estimates are reported for asa = 1 and lipid content = 10%.

	CL_i	CL_ae	t_lag	C_cell,AB Ratio	C_cell,BA Ratio
	μl/min		min
Atorvastatin	2.7	0.033	43.1	9.66	1.28
Loperamide	32.1	0.681	16.5	43.84	1.91
Labetalol	1.7	0.105	33.4	20.35	1.43
Pitavastatin	3.5	0.030	45.3	10.21	1.08
Minoxidil	0.3	0.021	20.1	2.53	1.26
Verapamil	15.7	0.147	8.7	6.38	1.92