. Author manuscript; available in PMC: 2015 Feb 1.

Published in final edited form as: Pharm Res. 2013 Aug 16;31(2):360–372. doi: 10.1007/s11095-013-1165-6

Table 1.

The effect of air inlet hole staggering on the mean drug deposition and aerosolization performance for CCs 1-5 coupled with the 3D rod array mouthpiece tested at a 4 kPa pressure drop. Coefficient of variation (%) is shown in parenthesis [n=3].

Description	CC₁-3D	CC₂-3D	CC₃-3D	CC₄-3D	CC₅-3D
Offset distance (mm)	0.00	0.41	0.83	1.24	1.65
Air inlet hole diameter (mm)	3.16	2.78	3.17	2.78	3.08
Air flow rate (L min⁻¹)	50	40	50	43	50
Emitted (%)^*	66.2 (1.8)	68.4 (3.6)	67.0 (10.0)	64.9 (17.3)	6.3 (63.9)^**
Capsule retention (%)^*	13.7 (10.5)	13.5 (17.4)	10.1 (6.7)	14.4 (50.3)	90.4 (5.4)^**
Capsule chamber retention (%)	6.1 (17.3)	5.4 (30.3)	12.0 (40.4)	9.8 (81.9)	2.1 (55.1)
Mouthpiece retention (%)^*	14.1 (4.4)	12.7 (8.0)	10.9 (21.7)	10.9 (21.2)	1.1 (37.7)^**
FPF_<5µm/ED (%)^*	93.8 (0.7)	93.6(1.1)	94.3 (3.0)	89.7 (1.0)	75.3 (16.4)^**
FPF_<1µm/ED (%)^*	30.9 (1.9)	32.7 (4.1)	31.7 (3.4)	28.6 (7.3)	20.8 (30.3)^**
MMAD (µm)^*	1.47(1.22)	1.46 (2.54)	1.44 (0.68)	1.55 (3.76)	1.83 (15.39)^**

P<0.05 significant effect of air inlet staggering on % emitted, capsule & mouthpiece retentions, FPF_<5µm/ED, FPF_<1µm/ED and MMAD (one-way ANOVA).

^**

P<0.05 significant effect of % emitted, capsule & mouthpiece retentions, FPF_<5µm/ED, FPF_<1µm/ED and MMAD compared to CC₁-3D (post-hoc Tukey).

Batch-1 EEG formulation combination particles generated by Büchi Nano Spray Dryer (B-90).