FIGURE 2.

Schematic diagram of signaling mediated by surface receptors and Panx1 in the injured retina. Although signaling by TNFRs, TLR4 (signals through MyD88 and/or TRIF) and Ca²⁺ can feed directly into NF-κB activation, TLR3 signaling via TRIF first results in the transcription of type 1 interferon genes. These can also promote NF-κB-regulated transcription (dashed arrow). Ultimately, the maturation of pro-IL-1β into IL-1β via inflammasome pathways perpeturates inflammation and worsens the glaucomatous damage.