Figure 2.

MSG and sucrose substitution initiated robust ethanol drinking in B6 mice. (A) MSG substitution with 15% ethanol produced robust ethanol intakes (●, g/kg/2 hr; x, mL/2 hr) across a range of both ethanol and MSG concentrations (A₁). During the MSG fade-out (A₂), ethanol drinking was relatively stable despite declining MSG concentrations. (B) In the sucrose-substitution group with B6 mice, ethanol intake (■, g/kg/2 hr; x, mL/2 hr) tended to remain relatively stable across sucrose concentrations when ethanol concentrations were > 3% (B₁). However, during the sucrose fade-out (B₂), ethanol drinking declined in parallel with declining sucrose concentrations.