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Inhibiting DRP-1 with Mdivi-1 induces long reticulated mitochondria within minutes without altering mitochondrial ATP production. A. Cultured RGCs labeled with mitotracker, before and 20 minutes after Mdivi-1 (20 μm). B. After Mdivi-1, mitochondrial length doubles in both the faster growing embryonic and the slow growing RGC axons. C. Neither acute nor chronic Mdivi-1 alters basal or maximal respiration or glycolysis [43]. Bar is 10 μm.
