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. Author manuscript; available in PMC: 2015 Feb 1.
Published in final edited form as: J Nutr Biochem. 2013 Nov 6;25(2):126–135. doi: 10.1016/j.jnutbio.2013.10.003

Fig. 1.

Fig. 1

Proposed signaling pathway for PCB detoxification in vivo. PCB 126, an AHR ligand and activator of NRF2, causes CYP1A1 upregulation, which leads to superoxide production. Green tea extract (GTE) diet supplementation effectively upregulates redox-related enzymes in the presence of PCB 126 which allows for a more efficient antioxidant response to environmental insult.