Table 2.
Anthropometric and lifestyle data for all genotyped subjects in the discovery sample for rs11057841; SD, standard deviation; BMI (Body mass index), MPOD, macular pigment optical density; AMD, Age-related Macular Degeneration.
| Characteristic | CC n=228 | CT n=64 | TT n=6 | P value | |||
|---|---|---|---|---|---|---|---|
| Age( years) | 47.8 | (11.4) | 48.4 | (10.2) | 51.2 | (10.4) | 0.28 |
| Sex Male, n (%) | 66 | 29% | 22 | 34% | 3 | 50% | |
| BMI (kg/m2) | 26.6 | (4.5) | 27.3 | (5.0) | 24.7 | (2.4) | 0.24 |
| MPOD Area | 0.713 | (0.436) | 0.734 | (0.411) | 0.735 | (0.507) | 0.70 |
| MPOD 0.25° | 0.477 | (0.208) | 0.494 | (0.201) | 0.500 | (0.231) | 0.85 |
| MPOD 0.5° | 0.376 | (0.171) | 0.392 | (0.185) | 0.348 | (0.255) | 0.15 |
| MPOD 1° | 0.239 | (0.128) | 0.240 | (0.129) | 0.203 | (0.132) | 0.76 |
| MPOD 1.75° | 0.126 | (0.097) | 0.125 | (0.095) | 0.138 | (0.106) | 0.63 |
| Pack years smoked | 5.997 | (11.94) | 4.811 | (9.222) | 5.667 | (9.136) | 0.26 |
| Serum Lutein (μg/mL) | 0.075 | [0.057-0.102] | 0.094 | [0.066-0.127] | 0.111 | [0.076-0.160] | 2×10−4 |
| Serum Zeaxanthin (μg/mL) | 0.013 | [0.009-0.200] | 0.014 | [0.009-0.200] | 0.016 | [0.010-0.021] | 0.85 |
| Dietary Lutein (mg) | 0.939 | [0.681-0.984] | 1.060 | [0.738-1.630] | 0.679 | [0.403-0.922] | 0.07 |
| Dietary Zeaxanthin (mg) | 0.156 | [0.109-0.238] | 0.158 | [0.111-0.215] | 0.127 | [0.087-0.198] | 0.20 |
| LDLc (mmol/L) | 3.211 | (0.910) | 3.271 | (0.968) | 2.780 | (1.017) | 0.83 |
| HDLc (mmol/L) | 1.491 | (0.380) | 1.509 | (0.372) | 1.715 | (0.505) | 0.98 |
| Triglycerides (mmol/L) | 1.167 | [0.087-1.490] | 1.281 | [0.785-1.728] | 0.942 | [0.628-1.238] | 0.17 |
| Total cholesterol (mmol/L) | 5.379 | (1.092) | 5.518 | (1.149) | 5.548 | (0.925) | 0.79 |
| Positive family history of AMD, n (%) | 83 | (36%) | 31 | (48%) | 4 | (67%) | |
rs11057841: data presented as mean (SD), geometric mean [IQR] or n (%).