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. Author manuscript; available in PMC: 2014 Mar 8.
Published in final edited form as: Ophthalmology. 2013 Apr 5;120(8):1632–1640. doi: 10.1016/j.ophtha.2013.01.030

Table 3.

Genotype effect size for rs11057841 on serum lutein concentration (log base 10 scale) estimated from an additive genetic model without adjustment for covariates in discovery and replication cohorts.

Cohort Allele MAF n Coefficient SE Change per allele (CI)2 P
Waterford (Discovery) T 0.13 298 0.094 0.025 1.24 (1.11-1.39) 2×10−4
TwinsUK (Replication) T 0.09 199 0.252 0.102 1.79 (1.13-2.83) 0.014
1CAREDS (Replication) C 0.15 1640 0.040 0.011 1.10 (1.04-1.15) 2×10−4

MAF = minor allele frequency; SE = standard error; CI = 95% confidence intervals.