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. Author manuscript; available in PMC: 2015 Feb 1.
Published in final edited form as: Acta Neuropathol. 2013 Oct 18;127(2):243–256. doi: 10.1007/s00401-013-1175-9

Fig. 7. Expression of I2CTF causes neurodegeneration and loss of neuronal plasticity.

Fig. 7

a, b: Fluoro-Jade B staining showed an increase in neurodegeneration in I2CTF rats; c: Western blots and their quantitative analysis showed a decrease in the level of βIII tubulin and not in total tubulin in I2CTF rats; d, e: Immunohistofluorescent staining showed a decrease in the density of MAP2 in CA1 and CA3, synapsin 1 in CA3, and synaptophysin in CA3 of the hippocampi of I2CTF rats; and f: Western blots and their quantitative analysis showed a marked decrease in the levels of MAP2, synapsin 1, and synaptophysin in the I2CTF rats’ hippocampus, cerebral cortex, subcortical area (SA) and cerebellum. Data from 14-month-old rats. *p<0.05; **p<0.01. Scale bar: a: 300 μm; inset: 100 μm; d: 500 μm.