Table 2.
Associations of H pylori and cagA Seroprevalence with Symptoms of Gastroesophageal Reflux, Erosive Esophagitis, or Barrett’s Esophagus.
|
H pylori / cagA Status |
# No GERD, EE, or BEb |
GERD | Erosive Esophagitis | Barrett’s Esophagus | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
| # GERD | Crude OR (95% CI) |
Adjusted OR (95% CI)a |
# EE | Crude OR (95% CI) |
Adjusted OR (95% CI) |
# BEb | Crude OR (95% CI) |
Adjusted OR (95% CI) |
||
| H pylori − | 131 | 115 | 1 (Reference) | 1 (Reference) | 182 | 1 (Reference) | 1 (Reference) | 125 | 1 (Reference) | 1 (Reference) |
| H pylori + | 46 | 38 | 0.94 (0.57, 1.55) |
0.95 (0.55, 1.64) |
40 | 0.63 (0.39, 1.01) |
0.63 (0.37, 1.08) |
25 | 0.57 (0.33, 0.98) |
0.53 (0.29, 0.97) |
| H pylori +, cagA − | 22 | 20 | 1.04 (0.54, 1.99) |
0.93 (0.46, 1.88) |
25 | 0.82 (0.44, 1.51) |
0.78 (0.40, 1.54) |
16 | 0.76 (0.38, 1.52) |
0.64 (0.30, 1.36) |
| H pylori +, cagA + | 23 | 18 | 0.89 (0.46, 1.74) |
0.97 (0.46, 2.03) |
15 | 0.47 (0.24, 0.93) |
0.47 (0.21, 1.03) |
8 | 0.365 (0.16, 0.85) |
0.36 (0.14, 0.90) |
a
Adjusted for age, waist-to-hip ratio, smoking status, education, and race.
BE: Barrett’s esophagus, CI: confidence interval, GERD: gastroesophageal reflux disease, EE: erosive esophagitis, OR: odds ratio
b
1 normal patient and 1 with BE was positive for H pylori, but had inadequate sample for assaying cagA.