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Leptin has a dose-dependent effect on both human and murine neutrophil migration. Human peripheral blood derived neutrophils (A) and murine isolated bone marrow-derived neutrophils (B) were exposed to control (C), IL-8 (100ng/mL) (human), KC (50ng/mL) (murine), and different concentrations of human and murine leptin in a modified Boyden chamber (n=4 for each condition). Data are presented as mean ± SEM. **** p≤0.0001 as performed with One-way ANOVA.
