Skip to main content
. Author manuscript; available in PMC: 2015 Jan 17.
Published in final edited form as: ACS Chem Biol. 2013 Nov 5;9(1):266–275. doi: 10.1021/cb4006408

Figure 1. Transglutaminase activity and chemical tools for investigating its role in PAH.

Figure 1

Transglutaminase 2 (TG2) catalyzes the formation of an isopeptide bond between a protein or peptide substrate harboring a target Gln residue and an acyl acceptor substrate, which may be a Lys residue on another protein or peptide or even a small molecule amine (panel A). One such biogenic amine substrate is serotonin (5-hydroxytryptamine, 5-HT). 5-biotinamidopentylamine (5BP) is another (unnatural) substrate for TG2 that is used as a probe for TG2 activity in tissues (panel B). ERW1041E (Panel C) (1) is an irreversible, acyl-donor substrate-competitive inhibitor of TG2.