Table 1. Epidemiological parameters.
Symbol | Parameter | Value (references) | |
---|---|---|---|
bm | Birth rate of mosquitoes | *Calibrated for constant population* | |
dO | Death rate of mosquitoes | 0.042 d−1 (44–48) | |
bh | Birth rate of humans | *Calibrated for constant population* | |
dh | Death rate of humans | 0.0000165 d−1 (49) | |
χ | Proportion of dengue infections that are symptomatic | 0.2 (28, 50, 51) | |
ε | Rate of loss of maternal antibodies | 0.0075 d−1 (52, 53) | |
δ | Rate of loss of cross-immunity | 0.0055 d−1 (4, 24, 28) | |
γ | Dengue fever (non-DHF) recovery rate | 0.1429 d−1 (28, 52, 53) | |
η1 | Rate of developing DHF after primary infection | 0.002 d−1 (8) | |
η2 | Rate of developing DHF after secondary/tertiary/quaternary infection | Age-dependent data (31) | |
α | Risk of death from DHF | 0.01 (54) | |
φ | DHF recovery rate | 0.2 d−1 (52) | |
c | Biting rate (number of bites per mosquito per day) | 0.7 (55) | |
σi | Relative probability of being susceptible to new infection after having i previous infections | ||
β0 | Percentage of human infected per bite | 0.5 (53, 56) | |
βm | Percentage of mosquito infected per bite | 0.9 (53, 56) | |
Rate of aging out of age group a | Proportional to the length of age group a | ||
Rate of aging into age group a | Proportional to the length of age group a−1 | ||
πa | Age-dependent relative probability of mosquito-to-human transmission | Thailand: πa = 1; Brazil: π1 = 0.1, π2 = 0.2, π3 = 0.3, π4 = 0.8, πj = 1, j = 5,6,7. *Calibrated to fit DHF profiles* |
|
Proportion of vaccinated individuals in age group a | Varied | ||
Veff | Vaccine efficacy | 0.75 |