Table 1b.
Baseline characteristics of patients with depression, ages 25–64 years, initiating antidepressant therapy before and after propensity score matching on the probability of receiving SNRI therapy
| Pre-Matched Cohort | Propensity Score Matched Cohort | |||
|---|---|---|---|---|
| Characteristic | SSRI N=225,952 |
SNRI N=36,037 |
SSRI N=72,028 |
SNRI N=36,037 |
| Age | ||||
| 25–40 | 93,806 (41.5%) | 13,227 (36.7%) | 26,992 (37.5%) | 13,227 (36.7%) |
| 41–55 | 96,389 (42.7%) | 16,712 (46.4%) | 32,307 (44.9%) | 16,712 (46.4%) |
| 56+ | 35,757 (15.8%) | 6,098 (16.9%) | 12,729 (17.7%) | 6,098 (16.9%) |
| Sex, M | 74,212 (32.8%) | 11,202 (31.1%) | 23,001 (31.9%) | 11,202 (31.1%) |
| Severity Level of Depression Diagnosis | ||||
| T1: Primary Inpatient diagnosis <=30 Days Pre-Index Date | 2,150 (1.0%) | 450 (1.2%) | 928 (1.3%) | 450 (1.2%) |
| T2: Primary Inpatient diagnosis 31–360 Days Pre-Index Date | 406 (0.2%) | 142 (0.4%) | 235 (0.3%) | 142 (0.4%) |
| T3: Non-Primary Inpatient diagnosis <=360 Days Pre-Index Date | 5,518 (2.4%) | 1,064 (3.0%) | 2,016 (2.8%) | 1,064 (3.0%) |
| T4: 2+ Outpatient Diagnosis <=360 Days Pre-Index Date | 116,171 (51.4%) | 20,737 (57.5%) | 37,969 (52.7%) | 20,737 (57.5%) |
| T5: 1 Outpatient Diagnosis <=360 Days Pre-Index Date | 101,707 (45.0%) | 13,644 (37.9%) | 30,880 (42.9%) | 13,644 (37.9%) |
| Anxiety Disorders | 54,993 (24.3%) | 9,402 (26.1%) | 19,517 (27.1%) | 9,402 (26.1%) |
| Baseline DSH | 519 (0.2%) | 93 (0.3%) | 185 (0.3%) | 93 (0.3%) |
| Primary Inpatient Depression Diagnosis | 2,556 (1.1%) | 592 (1.6%) | 1,163 (1.6%) | 592 (1.6%) |
| No Depression Diagnosis w/in 3 0 Days of Index Date | 45,707 (20.2%) | 10,522 (29.2%) | 21,068 (29.2%) | 10,522 (29.2%) |
| Baseline Suicidal Ideation (2006–2010 only) | 1,103 (0.8%) | 218 (0.9%) | 463 (1.0%) | 218 (0.9%) |
| Cognitive Impairment/Dementia | 242 (0.1%) | 47 (0.1%) | 95 (0.1%) | 47 (0.1%) |
| Personality Disorder | 1,269 (0.6%) | 257 (0.7%) | 554 (0.8%) | 257 (0.7%) |
| Substance Abuse | 20,334 (9.0%) | 3,630 (10.1%) | 7,853 (10.9%) | 3,630 (10.1%) |
| Use of Any Opiate | 72,807 (32.2%) | 13,668 (37.9%) | 27,456 (38.1%) | 13,668 (37.9%) |
| Number of Distinct Drug Prescriptions Filled | ||||
| 1 (Antidepressant Only) | 21,005 (9.3%) | 3,229 (9.0%) | 6,213 (8.6%) | 3,229 (9.0%) |
| 2–3 | 51,943 (23.0%) | 7,321 (20.3%) | 14,564 (20.2%) | 7,321 (20.3%) |
| 4–5 | 46,441 (20.6%) | 6,688 (18.6%) | 12,834 (17.8%) | 6,688 (18.6%) |
| 6–9 | 60,524 (26.8%) | 9,556 (26.5%) | 19,454 (27.0%) | 9,556 (26.5%) |
| 10+ | 46,039 (20.4%) | 9,243 (25.6%) | 18,963 (26.3%) | 9,243 (25.6%) |
| Number of Psychiatric Hospitalizations, 1+ | 2,694 (1.2%) | 608 (1.7%) | 1,197 (1.7%) | 608 (1.7%) |
| Number of Outpatient Visits | ||||
| <5 | 39,311 (17.4%) | 4,966 (13.8%) | 9,338 (13.0%) | 4,966 (13.8%) |
| 5–9 | 54,399 (24.1%) | 7,671 (21.3%) | 15,001 (20.8%) | 7,671 (21.3%) |
| 10–19 | 67,688 (30.0%) | 10,581 (29.4%) | 21,639 (30.0%) | 10,581 (29.4%) |
| 20–39 | 46,533 (20.6%) | 8,436 (23.4%) | 17,357 (24.1%) | 8,436 (23.4%) |
| 40+ | 18,021 (8.0%) | 4,383 (12.2%) | 8,693 (12.1%) | 4,383 (12.2%) |
| Number of Hospitalizations for Substance Abuse, 1+ | 1,192 (0.5%) | 241 (0.7%) | 524 (0.7%) | 241 (0.7%) |
| Number of Hospitalizations for Other Reasons, 1+ | 25,038 (11.1%) | 4,055 (11.3%) | 8,511 (11.8%) | 4,055 (11.3%) |
| Colorectal Cancer | 563 (0.2%) | 90 (0.2%) | 213 (0.3%) | 90 (0.2%) |
| Prostate Cancer | 636 (0.3%) | 101 (0.3%) | 224 (0.3%) | 101 (0.3%) |
| Other Malignant Neoplasm Cancer | 7,842 (3.5%) | 1,555 (4.3%) | 3,325 (4.6%) | 1,555 (4.3%) |
| Congestive Heart Failure | 2,477 (1.1%) | 449 (1.2%) | 938 (1.3%) | 449 (1.2%) |
| Arthritis | 2,110 (0.9%) | 576 (1.6%) | 1,143 (1.6%) | 576 (1.6%) |
| Cerebrovascular Disease | 4,777 (2.1%) | 875 (2.4%) | 1,838 (2.6%) | 875 (2.4%) |
| Cluster Headaches/Migraines | 10,188 (4.5%) | 2,256 (6.3%) | 4,642 (6.4%) | 2,256 (6.3%) |
| Diabetes | 17,361 (7.7%) | 3,235 (9.0%) | 6,737 (9.4%) | 3,235 (9.0%) |
| Disorders of the Eye | 285 (0.1%) | 49 (0.1%) | 105 (0.1%) | 49 (0.1%) |
| Gait or Balance Disorder | 2,426 (1.1%) | 522 (1.4%) | 1,065 (1.5%) | 522 (1.4%) |
| Hyperparathyroidism | 325 (0.1%) | 80 (0.2%) | 159 (0.2%) | 80 (0.2%) |
| Osteoarthritis | 14,325 (6.3%) | 3,217 (8.9%) | 6,528 (9.1%) | 3,217 (8.9%) |
| Osteoporosis | 3,776 (1.7%) | 863 (2.4%) | 1,758 (2.4%) | 863 (2.4%) |
| Parkinson’s Disease | 231 (0.1%) | 36 (0.1%) | 72 (0.1%) | 36 (0.1%) |
| Seizures | 1,641 (0.7%) | 302 (0.8%) | 686 (1.0%) | 302 (0.8%) |
| Urinary Incontinence | 2,421 (1.1%) | 547 (1.5%) | 1,152 (1.6%) | 547 (1.5%) |