Table 1. Association rate constant (Kon), dissociation rate constant (Koff), and dissociation constant (Kd) of various TNYL-RAW peptide derivatives from surface plasmon resonance analysis measured on immobilized EphB4 receptors.
| Analyte | Kon [M−1 s−1] | Koff [s−1] | Kd [M] | χ2 |
|---|---|---|---|---|
| DOTA-TNYL-RAW | 1.1 × 105 | 2.56×10−3 | 2.33−8 | 0.28 |
| Cy5.5-TNYL-RAW | 4.15×106 | 5.28×10−3 | 1.27−9 | 4.37 |
| Cy5.5-TNYL-RAWK-DOTA | 1.86× 106 | 1 87 × 1 0−3 | 1.01−9 | 5.67 |
| TNYL-RAW | 4.26×105 | 1.3× 10−3 | 3.06−9 | 0.155 |
The χ2 values indicate the quality of the fit