Severity	Description
Mild (1)	Transient or mild discomfort; no limitation in baseline activity; no medical intervention or therapy required. The subject may be aware of the sign or symptom, but tolerates it reasonably well.
Moderate (2)	Mild to moderate limitation from baseline activity, no or minimal medical intervention/therapy required.
Severe (3)	Marked limitation from baseline activity, medical intervention/therapy required, hospitalizations possible
Life- threatening/ disabling (4)	The subject is at risk of death due to the adverse event as it occurred. This does not refer to an event that hypothetically might have caused death if it were more severe.