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. Author manuscript; available in PMC: 2015 Feb 1.
Published in final edited form as: Traffic. 2013 Nov 14;15(2):212–229. doi: 10.1111/tra.12135

Figure 6.

Figure 6

In silico sorting of MVB cargo. A computer simulation of ESCRT-mediated cargo sorting was developed based on the rules listed in the text (for more detail see Materials and Methods). (A) The graphs show the sorting of cargo (indicated by the removal of cargo) averaged from 20 simulations as a function of simulation steps. The Y-axis indicates the % of the area occupied by the different components and thus represents concentration of that component on the membrane. (B) Snapshots of a simulation with five ESCRT-ESCRT interaction sites. Cargoes are in red, non-cargoes in green and ESCRT components in black. Black lines indicate interactions between components. A movie of this simulation can be found in Online Supplemental Material.