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. Author manuscript; available in PMC: 2015 Feb 20.
Published in final edited form as: Stat Med. 2013 Sep 30;33(4):569–579. doi: 10.1002/sim.5998

Table 2.

Toxicity scenarios 1–7 for the dose-schedule combinations. Combinations with DLT probabilities between 0.20 and 0.40 are in boldface.

Schedule Doses in mg/m2
8 16 24 8 16 24
Scenario 1 Scenario 2
D 0.22 0.26 0.30 0.31 0.45 0.62
C 0.16 0.18 0.23 0.18 0.32 0.54
B 0.09 0.12 0.18 0.09 0.21 0.40
A 0.05 0.07 0.11 0.03 0.14 0.28
Scenario 3 Scenario 4
D 0.55 0.62 0.72 0.57 0.73 0.78
C 0.45 0.50 0.62 0.55 0.65 0.75
B 0.30 0.32 0.50 0.53 0.60 0.65
A 0.10 0.26 0.35 0.50 0.54 0.58
Scenario 5 Scenario 6
D 0.30 0.48 0.70 0.50 0.60 0.75
C 0.14 0.32 0.55 0.30 0.50 0.60
B 0.12 0.30 0.48 0.12 0.30 0.50
A 0.10 0.28 0.45 0.03 0.15 0.30
Scenario 7
D 0.10 0.60 0.70
C 0.05 0.50 0.60
B 0.03 0.30 0.55
A 0.01 0.10 0.50