Table 3.

Summary statistics for BTNL and four applications of the proposed method: (1) complete order schedules, no stopping rule, (2) partial order schedules, no stopping rule, (3) complete order schedules, stopping rule, and (4) partial order schedules, stopping rule. Acceptable combination is defined as any combination within ± 10% of the target.

	Scenario
	1	2	3	4	5	6	7
Probability of selecting an acceptable combination as MTD
BTNL	0.87	0.81	0.88	n/a	0.71	0.72	0.54
Proposed (complete, no stop)	0.73	0.86	0.87	n/a	0.81	0.85	0.70
Proposed (partial, no stop)	0.78	0.84	0.82	n/a	0.82	0.84	0.64
Proposed (complete, stop)	0.62	0.75	0.73	n/a	0.64	0.69	0.49
Proposed (partial, stop)	0.64	0.76	0.69	n/a	0.65	0.66	0.43
Probability of selecting no combination as MTD
BTNL	0.00	0.00	0.01	0.90	0.00	0.00	0.00
Proposed (complete, no stop)	0.00	0.00	0.00	0.00	0.00	0.00	0.00
Proposed (partial, no stop)	0.00	0.00	0.00	0.00	0.00	0.00	0.00
Proposed (complete, stop)	0.00	0.00	0.01	0.24	0.01	0.00	0.00
Proposed (partial, stop)	0.00	0.00	0.01	0.25	0.01	0.00	0.00
Mean number of patients enrolled
BTNL	60.0	60.0	59.5	28.7	60.0	60.0	60.0
Proposed (complete, no stop)	60.0	60.0	60.0	29.0	60.0	60.0	60.0
Proposed (partial, no stop)	60.0	60.0	60.0	29.0	60.0	60.0	60.0
Proposed (complete, stop)	25.6	24.6	22.4	14.5	23.4	24.3	24.3
Proposed (partial, stop)	26.1	25.7	23.3	15.2	24.3	25.5	25.6
Observed incidence of toxicity
BTNL	0.22	0.29	0.34	0.54	0.31	0.31	0.33
Proposed (complete, no stop)	0.21	0.28	0.32	0.50	0.31	0.31	0.33
Proposed (partial, no stop)	0.21	0.29	0.34	0.53	0.30	0.32	0.31
Proposed (complete, stop)	0.18	0.26	0.33	0.52	0.28	0.30	0.29
Proposed (partial, stop)	0.18	0.27	0.34	0.52	0.29	0.31	0.30

For 1000 runs, the maximum simulation standard error is approximately 0.016.

BTNL: Braun, Thall, Nguyen, de Lima method.