Table 4.
Toxicity scenarios 8–13 for the dose-schedule combinations. Combinations with DLT probabilities between 0.20 and 0.40 are in boldface.
| Schedule | Doses in mg/m2 | |||||
|---|---|---|---|---|---|---|
| 8 | 16 | 24 | 8 | 16 | 24 | |
| Scenario 8 | Scenario 9 | |||||
| D | 0.22 | 0.26 | 0.30 | 0.31 | 0.45 | 0.62 |
| C | 0.09 | 0.12 | 0.18 | 0.09 | 0.21 | 0.40 |
| B | 0.16 | 0.18 | 0.23 | 0.18 | 0.32 | 0.54 |
| A | 0.05 | 0.07 | 0.11 | 0.03 | 0.14 | 0.28 |
| Scenario 10 | Scenario 11 | |||||
| D | 0.55 | 0.62 | 0.72 | 0.30 | 0.48 | 0.70 |
| C | 0.30 | 0.32 | 0.50 | 0.12 | 0.30 | 0.48 |
| B | 0.45 | 0.50 | 0.62 | 0.14 | 0.32 | 0.55 |
| A | 0.10 | 0.26 | 0.35 | 0.10 | 0.28 | 0.45 |
| Scenario 12 | Scenario 13 | |||||
| D | 0.50 | 0.60 | 0.75 | 0.10 | 0.60 | 0.70 |
| C | 0.12 | 0.30 | 0.50 | 0.03 | 0.30 | 0.55 |
| B | 0.30 | 0.50 | 0.60 | 0.05 | 0.50 | 0.60 |
| A | 0.03 | 0.15 | 0.30 | 0.01 | 0.10 | 0.50 |