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. Author manuscript; available in PMC: 2015 Feb 1.
Published in final edited form as: Stem Cells. 2014 Feb;32(2):414–423. doi: 10.1002/stem.1569

Figure 5.

Figure 5

Vinblastine treatment ameliorates the SPG4 axonal swelling phenotype. (A) Week 8 iSPG4-l7 neurons treated with 10 nM vinblastine for 24 hours appeared to have a reduction in axonal swellings compared to control cells, while no deleterious effects were observed. Scale bars: 20μm. (B) Quantification revealed that 10 nM vinblastine significantly reduced the number of axonal swellings. (C) Treatment with 10 nM vinblastine for 24 hours also reduced axonal swellings in spastin RNAi-1 neurons. Scale bars: 20μm. (D) Quantification of axonal swellings in cells treated with vehicle or 10 nM vinblastine. Data presented as mean ±SD. **P < 0.01.