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. Author manuscript; available in PMC: 2015 Jan 7.
Published in final edited form as: Structure. 2013 Nov 27;22(1):70–81. doi: 10.1016/j.str.2013.10.010

Figure 2. KyoT2 domain schematics and sequence comparison.

Figure 2

(A) The KyoT gene gives rise to three different isoforms: KyoT1, KyoT2, and KyoT3. KyoT1, KyoT2, and KyoT3 contain four, two, and three LIM domains, respectively. KyoT2 and KyoT3 contain a CSL-interaction domain (CSL-ID). (B) Figure shows KyoT2 constructs used in this study. (C) Sequence alignment of the RAM domains from murine Notch1-4, Drosophila Notch (dNotch), EBNA2 (Epstein-Barr virus nuclear antigen 2), the worm Notch receptor LIN-12, and the CSL-ID of KyoT2. The basic region, -HG- motif, φWφP motif, and -HG- motif are boxed and colored blue, orange, green, and magenta, respectively. See also Figure S1 for CD spectrum of KyoT2 (184-210).