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. Author manuscript; available in PMC: 2015 Feb 1.
Published in final edited form as: Auton Neurosci. 2013 Oct 25;180:32–42. doi: 10.1016/j.autneu.2013.10.005

Figure 3.

Figure 3

An example of cardiopulmonary chemoreflex responses in mean arterial pressure (MAP), heart rate (HR), renal (RSNA), pre-adrenal (pre-ASNA) and lumbar (LSNA) sympathetic nerve activity evoked by intra-atrial injections of phenylbiguanide (1–8 µg/kg) under control conditions (left panels), after stimulation of the NTS A2a adenosine receptors (middle panels) with the highest dose of the A2a agonist, CGS-21680 (20 pmol in 50 nl), and after combined blockade and subsequent stimulation of NTS A2a receptors (right panels). Recordings in left and medium panels were performed in one animal whereas recordings in right panel were performed in another animal. Stimulation of the A2a receptors in the NTS virtually abolished the cardiopulmonary chemoreflex responses.