. Author manuscript; available in PMC: 2015 Feb 1.

Published in final edited form as: Auton Neurosci. 2013 Oct 25;180:32–42. doi: 10.1016/j.autneu.2013.10.005

Table 1.

Changes in baseline values of MAP, HR, RSNA, pre-ASNA, and LSNA following bilateral NTS microinjections of selective A_2a adenosine receptor agonist, CGS-21680, and antagonist ZM-241385

	CGS-21680 pmol/ 50 nl			ZM-241385 40 pmol/ 100 nl
	0.2	2	20	ZM-241385 40 pmol/ 100 nl
MAP, Δ mmHg	−6 ± 4	−6 ± 3	−9 ± 4^#	−2 ± 4
HR, Δ bpm	−31 ± 5.^#	−30 ± 80^#	−55 ± 11^#	−11 ± 10
RSNA, Δ%	−15.3 ± 4.1 ^#	−17.7 ± 4.9^‡^#	−33.3 ± 6.5^*^‡^#	−3.4 ± 7.2
pre-ASNA, Δ%	2.6 ± 4.1^†^#	21.1 ± 6.0^*^†^‡^#	14.6 ± 8.3^†^‡^#	−6.0 ± 4.1
LSNA, Δ%	−6.1 ± 3.0^†	−8.6 ± 3.3^†^#	−15.4 ± 4.3^†^#	−3.5 ± 3.3

Values are means ± SE. MAP, mean arterial pressure; HR, heart rate; RSNA, renal sympathetic nerve activity; pre-ASNA, preganglionic adrenal sympathetic nerve activity; and LSNA, lumbar sympathetic nerve activity; CGS-21680 (0.2–20 pmol/50 nl); ZM-241385 (40 pmol/100 nl).

P < 0.05 vs. 0.2 pmol CGS;

^†

P<0.05 vs. RSNA;

^‡

P<0.05 ASNA vs. LSNA;

vs. 0