Table 3.

Interactions between Cdx1 and Cdx2 genetic variants and the risk factors of BE

Gene	SNP	Genotype#	Male OR (95% CI)	P value	≥50 years OR (95% CI)	P value	Hernia OR (95% CI)	P value
Cdx1	rs3756311	GG	0.63 (0.18 – 2.21)	0.47	2.12 (0.59 – 7.61)	0.25	1.26 (0.37 – 4.27)	0.71
		AG	1.70 (0.70 – 4.09)	0.24	1.74 (0.56 – 5.40)	0.34	1.3 (0.46 – 3.69)	0.62
		AA	1.12 (0.46 – 2.73)	0.81	1.97 (0.63 – 6.15)	0.24	0.99 (0.33 – 2.96)	0.98
	rs3776082	GG	6.70 (1.33 – 33.84)	0.02*	7.75 (0.92 – 64.99)	0.06	0.59 (0.16 – 2.15)	0.42
		AG	13.60 (3.01 – 61.43)	<0.001**	19.73 (2.54 – 153.09)	0.004**	3.44 (1.37 – 8.61)	0.01*
		AA	19.01 (3.93 – 92.01)	<0.001**	19.57 (2.41 – 158.85)	0.005**	3.96 (1.40 – 11.14)	0.01*
	rs2237091	GG	2.76 (1.08 – 7.05)	0.03*	1.63 (0.61 – 4.31)	0.33	1.6 (0.63 – 4.06)	0.32
		AG	1.62 (0.69 – 3.78)	0.27	1.22 (0.49 – 3.01)	0.67	1.16 (0.51 – 2.65)	0.72
		AA	0.85 (0.31 – 2.37)	0.76	0.66 (0.24 – 1.87)	0.44	0.37 (0.13 – 1.09)	0.07
	rs717746	TT	2.80 (0.84 – 9.33)	0.09	11.77 (1.43 – 96.55)	0.02*	0.85 (0.27 – 2.69)	0.78
		GT	5.92 (2.05 – 17.1)	0.001**	21.09 (2.71 – 163.83)	0.003**	3.19 (1.27 – 8.03)	0.01*
		GG	10.15 (3.25 – 31.7)	<0.001**	29.10 (3.63 – 233.22)	0.001**	3.93 (1.42 – 10.89)	0.01*
	rs3776083	GG	2.68 (1.11 – 6.44)	0.03*	4.96 (1.82 – 13.53)	0.001**	2.73 (1.14 – 6.54)	0.02*
		AG	5.09 (2.16 – 12.00)	<0.001**	8.43 (3.20 – 22.22)	<0.001**	4.24 (1.84 – 9.74)	<0.001**
		AA	7.33 (2.17 – 24.70)	0.001**	3.69 (0.91 – 14.99)	0.07	3.28 (0.99 – 10.93)	0.05*
Cdx2	rs4769585	TT	1.94 (0.47 – 8.04)	0.36	1.91 (0.34 – 10.71)	0.46	9.86 (1.10 – 88.31)	0.04*
		CT	5.70 (1.71 – 18.95)	0.004**	6.68 (1.36 – 32.78)	0.02*	15.24 (1.88 – 123.34)	0.01*
		CC	7.06 (2.03 – 24.64)	0.002**	4.58 (0.91 – 23.00)	0.06	21.54 (2.57 – 180.76)	0.004**
	rs3812863	GG	1.35 (0.40 – 4.55)	0.62	∞ (0 – ∞)	0.99	10.22 (2.00 – 52.29)	0.005**
		AG	4.92 (1.74 – 13.88)	0.002**	∞ (0 – ∞)	0.98	12.53 (2.74 – 57.36)	0.001**
		AA	3.99 (1.31 – 12.10)	0.01*	∞ (0 – ∞))	0.98	12.94 (2.69 – 62.30)	0.001**
	rs2504211	GG	2.37 (1.22 – 4.62)	0.01*	3.98 (1.83 – 8.68)	<0.001**	1.61 (0.83 – 3.15)	0.16
		GT	3.67 (1.70 – 7.92)	<0.001**	4.25 (1.83 – 9.86)	<0.001**	2.31 (1.06 – 5.01)	0.03*
		TT	1.07 (0.19 – 6.09)	0.94	1.13 (0.20 – 6.28)	0.89	1.03 (0.24 – 4.56)	0.96
	rs1805107	GG	3.94 (0.27 – 58.07)	0.32	1.57 (0.10 – 23.87)	0.75	∞ (0 – ∞)	0.98
		AG	12.75 (1.42 – 114.42)	0.02*	5.67 (0.58 – 55.42)	0.14	∞ (0 – ∞)	0.98
		AA	8.00 (0.92 – 69.22)	0.06	5.02 (0.53 – 47.82)	0.16	∞ (0 – ∞)	0.98
	rs2481952	CC	2.89 (1.00 – 8.38)	0.05*	4.89 (1.43 – 16.79)	0.01*	8.30 (2.16 – 31.92)	0.002**
		CT	4.51 (1.72 – 11.83)	0.002**	6.53 (2.06 – 20.72)	0.001**	7.32 (2.02 – 26.60)	0.002**
		TT	5.00 (1.72 – 14.56)	0.003**	7.42 (2.12 – 26.06)	0.001**	8.89 (2.26 – 35.07)	0.002**
Unknown	rs9257809	AA	2.84 (1.62 – 4.96)	0.001**	2.94 (1.57 – 5.52)	0.001**	2.29 (1.31 – 4.01)	0.004**
		AG	3.61 (1.35 – 9.64)	0.01*	3.39 (1.25 – 9.17)	0.02*	2.07 (0.77 – 5.58)	0.15
		GG	∞ (0 – ∞)	0.99	∞ (0 – ∞)	0.99	∞ (0 – ∞)	0.99
Unknown	rs9936833	TT	2.38 (1.09 – 5.22)	0.03*	1.90 (0.82 – 4.39)	0.13	2.27 (1.03 – 4.98)	0.04*
		TC	3.95 (1.80 – 8.70)	0.001**	2.69 (1.16 – 6.21)	0.02*	2.48 (1.15 – 5.34)	0.02*
		CC	2.99 (1.13 – 7.98)	0.03*	4.70 (1.72 – 12.88)	0.003**	3.35 (1.32 – 8.52)	0.01*

^*Significant P value without correction for multiple testing;

^**Significant P value after Bonferroni correction (α = 0.05/10 or 0.005);

^#The first genotype of each SNP is a wild-type allele.