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. Author manuscript; available in PMC: 2015 Jan 1.
Published in final edited form as: Calcif Tissue Int. 2013 Sep 4;94(1):25–34. doi: 10.1007/s00223-013-9774-y

Figure 2. Gene expression at different stages of osteocyte development and maturation.

Figure 2

The osteocyte phenotype is characterized by the expression of groups of genes closely related to their morphology and function. Expression of some of these genes changes at different stages of osteocyte development and maturation. Boxes group four main categories: 1) Genes related to dendritic morphology and canaliculi formation; 2) genes related to phosphate metabolism and matrix mineralization; 3) genes that regulate bone formation; and 4) genes that regulate bone resorption. Please, note that several of these genes are also expressed in other cell types, besides cells of the osteoblastic lineage. (Reprinted with kind permission of Elsevier, Basic and Applied Bone Biology, Chapter 2 Bone Cells, Bellido, Plotkin and Bruzzaniti).