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. Author manuscript; available in PMC: 2015 Jan 1.
Published in final edited form as: Pharmacol Res. 2013 Nov 4;79:21–27. doi: 10.1016/j.phrs.2013.10.006

Fig. 2.

Fig. 2

Effect of RTX delivered s.c. on immobility in the forced swim test. Mice were injected with vehicle or either a low dose of RTX (0.02 mg/kg) or 3–5 injections of a high dose of RTX (0.1 mg/kg) and then subjected to 2 daily 15-min swims in baths maintained at either 26°C (panels A and B) or 41°C (panels C and D). Immobility in the two vehicle-injected control groups did not differ from each other, so they were pooled. The first forced swim occurred 24 h after the final injection of RTX. Comparisons between the effects of the two doses of RTX and vehicle (on the same day and at the same swim temperature) were performed using one-way ANOVA followed by Tukey’s post-hoc analysis and marked with an asterisk (*) when significant (panels A and C). Comparisons between immobility during swims on day 1 and day 2 (the same treatment and water temperature) were performed using Student’s t-test and marked with a pound sign (#) when significant (panels B and D).