Fig. 4.

Effect of antidepressants on RTX-induced increases in immobility. Mice were injected with RTX (0.02 mg/kg s.c.) and tested 24 h later in the forced swim test at 41°C. In panel A, in addition to RTX, mice were injected with either saline or amitriptyline (AMI, 10 mg/kg i.p.) 1 h before the RTX and 1 h before the swim. In panel B, mice were injected with saline or ketamine (KET, 50 mg/kg i.p.) 45 min before the RTX and 45 min before the swim. Comparisons between different treatments were performed using one-way ANOVA followed by Tukey’s post-hoc analysis and marked with an asterisk (*) when they differed.