Fig. 2.

HFD induces retinal TXNIP expression and NLRP3 inflammasome activation. Representative blots (a) and western blot analysis of TXNIP (b), NLRP3 (c), cleaved caspase-1 (Casp-1) (d) and cleaved IL-1β (e) protein levels in retinas of control rats (W) or SHR fed with normal diet or HFD (W+F and SHR+F) for 10 weeks. Protein levels were normalised to β-actin and respective W controls. n = 3–8; *p<0.05 vs W; ^†p<0.05 vs SHR; ^‡p<0.05 vs W+F