Skip to main content
. Author manuscript; available in PMC: 2015 Jan 1.
Published in final edited form as: Cancer Res. 2013 Nov 12;74(1):173–187. doi: 10.1158/0008-5472.CAN-13-0275

Figure 2. Antibody-mediated clustering promotes an adhesive phenotype.

Figure 2

(A) Dose-dependent inhibition of HEp3 cell migration in response to mAB 1A5 using an in vitro wound healing assay. (B) Dose-dependent inhibition of HEp3 cell migration in the CAM of chick embryos in response to mAB 1A5 treatment. (C) Collagen contraction by HT1080 cells in response to mAB 1A5 when compared to control IgG, inhibition of MMP activity (GM6001) and blocking of collagen binding (α2β1). (D) Fibronectin fibrilogenesis in response to mAB 1A5 or control IgG treatment as detected by immunofluorescent staining of fibronectin fibrils. (E) Platelet aggregation in response to mAB 1A5 treatment in the presence or absence of RGDS peptides to block integrin-mediated adhesions.