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. Author manuscript; available in PMC: 2015 Jan 1.
Published in final edited form as: Cancer Res. 2013 Nov 6;74(1):363–373. doi: 10.1158/0008-5472.CAN-13-2016

Figure 2. 14-3-3ζ accelerated Neu-mediated mammary tumorigenesis and metastasis.

Figure 2

A, Multiparous WAP-ζ.neu mice (n=8) had a shorter mammary tumor onset latency compared to multiparous MMTV-neu mice (n=21). B, Virgin MMTV-ζ.neu mice (n=9) had a shorter mammary tumor onset latency compared to virgin MMTV-neu mice (n=22). C, Neu and HA-14-3-3ζ protein IB in mammary glands and tumors from WAP-ζ.neu, MMTV-ζ.neu and MMTV-neu mice. D, H&E of mammary tumors from MMTV-neu (DCIS), MMTV-ζ.neu and WAP-ζ.neu (invasive) mice (X100). E, Incidence of lung metastases in MMTV-ζ.neu (6/9) mice is higher than MMTV-neu (5/22) mice. Lung metastases H&E (X200).