Table 2.

Multivariate cox regression analysis of the decrease of TGR and the RMH prognostic score for Progression-free survival (PFS) and Overall survival (OS).

	Progression-free survival (PFS)		Overall survival (OS)
	Hazard ratio 95% CI	P Value	Hazard ratio 95% CI	P Value
Decrease of Tumor Growth Rate*	0.91 0.85 – 0.96	0.004	0.95 0.88 – 1.04	0.27
RMH prognostic score low score (0–1) vs. high score (2–3)	1.42 0.96 – 2.08	0.08	2.53 1.47 – 4.34	0.0008

All the analyses reported are performed with the landmark method (landmark point was set to 56 days, n=157 patients analyzed).

^*To be clinically meaningfull, hazard ratios are computed for 10% variation in Tumor Growth Rate. Here, every 10% decrease in TGR between the REFRENCE and the EXPERIMENTAL periods results in a 9% decrease in the progression hazard.