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. Author manuscript; available in PMC: 2015 Jan 1.
Published in final edited form as: Clin Cancer Res. 2013 Nov 15;20(1):246–252. doi: 10.1158/1078-0432.CCR-13-2098

Table 2.

Multivariate cox regression analysis of the decrease of TGR and the RMH prognostic score for Progression-free survival (PFS) and Overall survival (OS).

Progression-free survival (PFS) Overall survival (OS)
Hazard ratio 95% CI P Value Hazard ratio 95% CI P Value
Decrease of Tumor Growth Rate* 0.91
0.85 – 0.96		 0.004 0.95
0.88 – 1.04		 0.27
RMH prognostic score low score (0–1) vs. high score (2–3) 1.42
0.96 – 2.08		 0.08 2.53
1.47 – 4.34		 0.0008

All the analyses reported are performed with the landmark method (landmark point was set to 56 days, n=157 patients analyzed).

*

To be clinically meaningfull, hazard ratios are computed for 10% variation in Tumor Growth Rate. Here, every 10% decrease in TGR between the REFRENCE and the EXPERIMENTAL periods results in a 9% decrease in the progression hazard.