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. Author manuscript; available in PMC: 2014 Jul 1.
Published in final edited form as: Nat Med. 2013 Dec 15;20(1):75–79. doi: 10.1038/nm.3412

Figure 1. Serial imaging reveals the dynamic evolution of lesions in TB.

Figure 1

(a) A PET/CT image of progressing and regressing lesions is shown from the same animal that developed active disease following low dose infection. Serial PET/CTs reveal a resolving lesion in the right upper lobe (upper panel, solid black arrows) at the same time that new lesions appear (dashed black arrow). In the right lower lobe (lower panel), lesions progress (dashed black arrows) and new lesions coalesce to form a consolidation (circles). (b) 18-FDG avidity (SUVR) is positively correlated with bacterial numbers in lesions (Spearman’s • = 0.4431), though there is considerable variability in both. A linear regression model of SUVR vs. CFU reveals significant predictive value (slope = 0.05847 +/− 0.009730, p < 0.001). Symbols represent individual lesions (n = 274) from active (green, n = 15) or latent (blue, n = 10) monkeys.