Table 2.

Levels of Oxidized Nucleic Acid Base Adducts in nuclear DNA expressed as % of NC (Median [Range])

		Brain Region
8OHG	NC	100.0 [37.4–337.9]	100.0 [40.7–184.3]	100.0 [45.6–126.2]
	PCAD	492.8 [118.9–4751.5]**	605.6 [97.5–1873.3]**	204.7 [83.1–323.3]**
	MCI	156.1 [78.4–1110.2]	444.5 [212.7–759.3]**	89.9 [73.0–110.5]
	LAD	377.5 [101.9–2140.5]**	107.7 [57.5–1003.5]	249.3 [72.9–406.0]***
	DC	219.0 [62.4–2226.7]***	105.7 [39.9–352.3]	419.2 [160.7–928.0]**
FapyG	NC	100.0 [57.3–235.0]	100.0 [71.7–133.8]	100.0 [28.1–205.4]
	PCAD	145.1 [85.0–455.8]*	106.1 [61.8–286.7]	105.3 [53.9–225.9]
	MCI	173.6 [59.0–197.6]	106.8 [30.8–167.5]	106.6 [71.3–225.0]
	LAD	141.9 [84.3–294.5]*	91.3 [41.5–169.0]	110.3 [79.3–214.7]
	DC	100.4 [56.5–245.8]	93.3 [44.3–172.6]	134.3 [77.0–177.6]
8OHA	NC	100. [40.2–556.5]	100.0 [31.2–206.8]	100.0 [29.0–200.1]
	PCAD	329.1 [95.8–1143.6]**	245.3 [95.1–1572.2]**	373.5 [60.9–518.6]**
	MCI	119.7 [73.1–171.8]	308.4 [184.0–398.5]**	85.0 [22.2–136.0]
	LAD	111.7 [43.9–373.7]	194.3 [122.6–1469.2]**	248.3 [44.8–1280.3]***
	DC	122.0 [58.4–256.4]	356.0 [124.4–629.6]**	135.3 [37.5–386.2]**
FapyA	NC	100.0 [53.4–149.9]	100.0 [52.6–343.6]	100.0 [53.5–212.4]
	PCAD	99.0 [58.0–205.5]	78.1 [29.4–159.2]	153.4 [86.6–172.8]
	MCI	94.6 [72.8–111.4]	111.6 [35.7–214.5]	126.8 [67.6–194.9]
	LAD	106.7 [45.5–210.7]	104.7 [29.5–158.7]	129.8 [55.2–174.8]
	DC	134.7 [82.5–241.1]	77.8 [30.6–146.5]	157.4 [19.9–228.1]
5OHC	NC	100.0 [48.9–128.1]	100.0 [64.7–204.3]	100.0 [46.5–710.0]
	PCAD	104.7 [44.9–209.7]	132.1 [49.2–355.9]	286.9 [76.2–789.1]
	MCI	85.7 [65.3–110.9]	164.0 [44.9–345.0]	187.0 [48.8–789.1]
	LAD	87.2 [59.6–211.7]	80.4 [56.0–166.1]	127.9 [61.4–127.9]
	DC	96.6 [44.9–153.4]	84.4 [34.2–177.9]	105.4 [29.5–354.1]

^*p ≤ 0.1 compared to NC

^**p ≤ 0.005 compared to NC

^***p ≤ 0.05 compared to NC