Table 3.

Levels of Oxidized Nucleic Acid Base Adducts in mitochondrial DNA expressed as % of NC (Median [Range])

		Brain Region
8OHG	NC	100.0 [30.3–144.1]	100.0 [51.6–194.3]	100.0 [70.4–176.1]
	PCAD	141.2 [84.1–241.8]*	313.5 [102.1–665.1]**	86.8 [28.6–353.8]
	MCI	201.3 [119.5–340.1]**	153.8 [54.0–386.7]	83.8 [57.7–222.5]
	LAD	182.0 [121.3–295.0]**	361.2 [209.6–837.9]**	186.8 [140.9–330.1]**
	DC	132.2 [90.0–327.8]*	250.1 [56.7–417.8]***	376.7 [100.8–976.7]**
FapyG	NC	100.0 [90.1–156.2]	100.0 [79.6–172.7]	100.0 [53.8–142.1]
	PCAD	110.9 [88.0–163.4]***	164.6 [75.0–230.7]**	136.9 [34.8–311.5]***
	MCI	121.3 [90.1–156.2]**	138.1 [115.7–157.2]	187.0 [137.8–214.2]**
	LAD	129.2 [115.6–186.0]**	192.0 [136.8–272.0]**	180.0 [117.6–266.8]**
	DC	112.5 [87.2–193.6]***	191.4 [164.8–367.7]**	194.5 [124.3–220.5]**
8OHA	NC	100.0 [65.2–129.5]	100.0 [36.3–181.0]	100.0 [73.9–307.2]
	PCAD	154.7 [90.9–280.2]**	319.1 [205.7–415.1]**	98.4 [55.9–292.2]
	MCI	170.7 [128.0–213.5]**	293.5 [155.4–372.9]**	80.9 [56.3–135.6]
	LAD	141.4 [117.9–276.9]**	537.5 [278.0–651.4]**	153.7 [103.5–295.5]**
	DC	162.0 [120.5–262.7]**	532.4 [289.9–693.8]**	185.2 [121.4–300.4]**
FapyA	NC	100.0 [48.5–153.0]	100.0 [70.3–175.7]	100.0 [70.3–226.1]
	PCAD	127.7 [97.2–177.6]**	131.8 [109.6–236.6]**	144.4 [70.6–320.8]*
	MCI	116.9 [70.7–203.1]	134.0 [87.1–220.8]	82.7 [45.1–211.2]
	LAD	130.1 [82.1–163.7]**	158.0 [115.6–219.6]**	175.3 [140.4–347.0]**
	DC	123.4 [66.0–183.5]*	145.2 [75.8–212.7]*	160.1 [93.8–256.8]**
5OHC	NC	100.0 [36.0–130.7]	100.0 [65.5–201.3]	100.0 [47.1–256.3]
	PCAD	129.9 [96.8–191.5]**	90.7 [62.2–120.8]	104.2 [54.4–168.5]
	MCI	113.5 [96.8–143.8]	121.5 [75.6–260.5]	87.2 [49.3–104.9]
	LAD	122.5 [90.4–191.8]**	88.4 [48.4–153.9]	76.4 [50.9–105.8]
	DC	102.4 [91.5–200.5]*	95.8 [66.4–169.4]	107.9 [79.1–129.1]

^*p ≤ 0.1 compared to NC

^**p ≤ 0.005 compared to NC

^***p ≤ 0.05 compared to NC