Table 1.

Percent change from baseline drinking behavior of vehicle-treated controls following treatment with either ADX71441 (3, 10, 30 mg/kg, p.o.) or naltrexone (0.1, 1, 10 mg/kg, i.p.) on the test days of the drinking-in-the-dark (DID) procedure. Volumes of ethanol (ml) were measured at 1, 2, 3, and 4 h time periods during an access test session, and percent change was calculated from 100 % baseline. Each point represents the observed mean (+SEM)

Drug dose		1 h	2 h	3 h	4 h
ADX71441	3 mg/kg	−25.93±11.92 %	−23.12±7.29 %	−9.84±6.84 %	−4.83±8.82 %
	10 mg/kg	−70.44±13.55*	−57.53±8.28**	−36.11±5.39**	−25.11±7.68*
	30 mg/kg	−80.73±4.11**	−86.04±4.05**	−80.99±4.39**	−69.57±3.89**
Naltrexone	0.1 mg/kg	−38.09±10.22*	−4.40±7.82	−0.28±6.12	−6.85±5.18
	1 mg/kg	−46.29±6.09*	−5.49±7.14	4.39±4.88	−0.53±5.30
	10 mg/kg	−56.67±11.04**	−29.84±10.43*	−10.03±11.79	−7.16±10.27

^*p <0.05,

^**p <0.01 vs. vehicle injection