Table 2.

Percent change from baseline drinking behavior of vehicle-treated controls following treatment with either ADX71441 (3, 10, 17 mg/kg, p.o.) or naltrexone (0.1, 1, 10 mg/kg, i.p.) on the test days of the intermittent access to ethanol (IA) procedure. Volumes of ethanol and water (milliliter) were measured at 2, 4, and 24 h time periods during an access test session, and percent change was calculated from 100 % baseline. Each point represents the observed mean (+SEM)

Drug dose		2 h	4 h	24 h
Ethanol
ADX71441	3 mg/kg	−3.92±12.96 %	−8.21±7.51 %	0.31±6.16 %
	10 mg/kg	−37.54±18.17	−29.60±10.55*	−10.12±5.36
	17 mg/kg	−66.39±10.30*	−44.07±9.06**	−15.30±4.81*
Naltrexone	0.1 mg/kg	−18.80±9.61	1.78±10.37	8.33±4.82
	1 mg/kg	−7.28±7.98	−13.05±8.42	−2.34±2.31
	10 mg/kg	−35.59±7.14*	−26.55±6.66	−7.74±2.73
Water
ADX71441	3 mg/kg	46.78±40.53	17.35±22.27	−7.73±19.28
	10 mg/kg	55.56±45.39	19.72±20.18	9.05±18.21
	17 mg/kg	−26.90±22.63	−9.62±13.96	10.83±11.73
Naltrexone	0.1 mg/kg	−1.30±18.88	−29.44±9.75	10.48±13.47
	1 mg/kg	−28.31±9.98	−17.50±12.68	2.65±10.05
	10 mg/kg	5.59±21.71	30.81±22.77	18.27±12.04

^*p <0.05,

^**p <0.01 vs. vehicle injection