Table 3.
Pharmacokinetic parameters following oral administration of 10 mg/kg ADX71441 to male C57BL/6 mice (n =24). Pharmacokinetic data shown are peak concentration (Cmax), area under the concentration time curves (AUClast and AUC0-∞), the terminal half-life value (T1/2), and time for the peak concentration (Tmax)
| Dose (mg/kg) | Plasma concentration ± SD at 1 h (ng/ml) | Plasma concentration ± SD at 4 h (ng/ml) | Plasma concentration ± SD at 24 h (ng/ml) | C max ± SD (ng/ml) | AUClasta ± SD (ng h/ml) | AUC0–8 (ng h/ml) | T 1/2 (h) | T max (h) |
|---|---|---|---|---|---|---|---|---|
| 10 (p.o.) | 629±61 | 487±62 | 36.4±33 | 673±50 | 6,700±309 | 6,970 | 5.3 | 2 |
a
Tlast=24 h