Table 1.
Clinical Characteristics
| Controls (n=20) |
MetS (n=27) |
p Value | |
|---|---|---|---|
| Age, year | 45 ± 2.5 | 49 ± 1.9 | 0.24 |
| Sex, female % | 65 | 63 | 0.57 |
| Height, cm | 169 ± 2 | 169 ± 2 | 0.92 |
| Weight, kg | 71 ± 2 | 103 ± 4 | <0.001 |
| Waist circumference, cm | 85 ± 5 | 119 ± 5 | <0.001 |
| Body Fat, % | 25 ± 2 | 39 ± 2 | <0.001 |
| Lean mass, kg | 53 ± 2 | 62 ± 2 | <0.01 |
| BSA, m2 | 1.80 ± 0.03 | 2.11 ± 0.04 | <0.001 |
| BMI, kg/m2 | 25.0 ± 0.8 | 36.0 ± 1.0 | <0.001 |
| SBP, mmHg* | 115 ± 2 | 134 ± 3 | <0.001 |
| DBP, mmHg* | 75 ± 1 | 83 ± 1 | <0.001 |
| Ejection Fraction, % | 61 ± 1 | 58 ± 1 | 0.06 |
| Triglycerides, mg/dL | 94 ± 10 | 170 ± 29 | 0.036 |
| HDL, mg/dL | 55 ± 3 | 43 ± 2 | <0.001 |
| Glucose, mg/dL | 93 ± 2 | 99 ± 1 | 0.018 |
| HbA1c, % | 5.35 ± 0.09 | 5.60 ± 0.07 | 0.03 |
| Insulin, µIU/mL | 6.1 ± 1 | 12.1 ± 1 | <0.001 |
| HOMA-IR | 1.32 ± 0.23 | 2.98 ± 0.37 | <0.001 |
| Hypertensive % | 0 | 56 % | <0.01 |
| Diabetes Mellitus % | 0 | 0 | |
| Medications | |||
| Hypertension | 0 | 56% | <0.05 |
| Cholesterol | 0 | 7% | <0.05 |
Values are mean ± 1 SEM; BSA: body surface area; BMI: body mass index; SBP: systolic blood pressure; DBP: diastolic blood pressure; HDL: high density lipoprotein; HbA1c: hemoglobin A1c; HOMA-IR: homeostatic model assessment of insulin resistance.
*
SBP and DBP taken during screening visit