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. Author manuscript; available in PMC: 2014 Aug 1.
Published in final edited form as: Nat Nanotechnol. 2014 Jan 26;9(2):148–155. doi: 10.1038/nnano.2013.309

Figure 5. Renal elimination and tumour accumulation of superstructures.

Figure 5

a, Total gold content in mice urine up to 48 hours following systemic injection of various superstructure components. b, Total gold content in mice urine up to 48 hours following systemic injection of superstructures assembled from the smallest satellite nanoparticles in a. Results show that urinary excretion of superstructures mirrors closely with their respective satellites building blocks. c, Tumour accumulation of core-satellite superstructures using 5nm-PEG10k satellite nanoparticles at 24 hours post-injection. Injection of core nanoparticles alone and mixtures of unassembled superstructure components were used as separate controls. Error bars represent S.E.M. from three to five independent replicates; *P<0.05, **P<0.01, ***P<0.001. d, Whole-animal imaging using fluorescently-labelled superstructures show tumour-specific accumulation (white arrow) as well as accumulation in the liver (yellow arrow). ID=injected dose.