Table 5.

Associated Gene Found in the NTHIPATHWAY Gene Set

	Probe	Rank in Gene List	Rank Metric Score	Running Es	Core Enrichment
1	ILIB*	0	3.264	0.3542	Yes
2	IL8*	8	2.035	0.5747	Yes
3	DUSP1	961	0.461	0.5703	Yes
4	NFKBIA	1,052	0.439	0.6128	Yes
5	NR3C1	1,116	0.428	0.6556	Yes
6	EF300	1,747	0.320	0.6543	Yes
7	CREBBP	1,812	0.311	0.6844	Yes
8	TGFBR1	2,068	0.279	0.7002	Yes
9	IKBKB	3,348	0.180	0.6466	No
10	MAP2K6	3,627	0.165	0.6486	No
11	TLR2	4,454	0.126	0.6151	No
12	RELA	4,626	0.119	9.6182	No
13	MAPK14	5,538	0.082	0.5750	No
14	MAPK11	5,719	0.075	0.5729	No
15	TGFBR2	6,135	0.058	0.5554	No
16	CHUK	6,171	0.057	0.5596	No
17	MAP3K7	6,989	0.029	0.5160	No
18	NFKB1	7,241	0.020	0.5039	No
19	MYD88	8,062	−0.006	0.4576	No
20	MAP2K3	10,744	−0.094	0.3146	No
21	MAP3K14	12,052	−0.142	0.2553	No
22	TNF	16,472	−0.524	0.0597	No

A detailed look into this gene set shows that IL-1b and IL-8 are the top-ranked genes in our experimental Aβ dataset. Genes that are found in the leading edge of this gene set are marked “Yes”in the core enrichment column. They are the genes that significantly contribute to the total enrichment score of the NTHIPATHWAY gene set.