Skip to main content
. Author manuscript; available in PMC: 2014 Mar 9.
Published in final edited form as: Invest Ophthalmol Vis Sci. 2013 Mar 1;54(3):2225–2237. doi: 10.1167/iovs.12-10849

Figure 8.

Figure 8

Microglia response to Aβ 1-40 stimulation. Retinal sections were reacted with OX-42 antibody against cell surface marker CD11b/c, representative of total microglia. (A–C) Representative immunoreactivity pattern of CD11b/c labeling in the retinal sections on day 1. Note that the Aβ section and the reverse peptide section both contain CD11b/c-positive cells within the GCL and INL (arrows), with the vehicle group demonstrating significantly lower CD11b/c immunoreactivity. Some CD11b/c-positive cells demonstrate rounded morphology and are intimately associated with cell bodies of retinal neurons (inset). (D) Bar graph of mean CD11b/c immunoreactivity profiles in three groups, with significance demonstrated at day 1 between the Aβ 1-40 forward peptide group and the reverse peptide and vehicle control groups. Micrographs were examined at ×20 and ×60 magnification. Scale bar: 20 μm; 5 μm (inset). Error bars: standard deviation. *P < 0.01.