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. Author manuscript; available in PMC: 2014 Mar 9.
Published in final edited form as: Neurotoxicology. 2011 Mar 17;32(4):392–399. doi: 10.1016/j.neuro.2011.03.002

Figure 3.

Figure 3

In HEK 293 cells expressing NR1a/NR2A and NR1a/NR2B receptors, CGX-1007 inhibits NMDA-gated currents in a concentration dependent manner. A, B: NMDA-gated currents evoked by NMDA (100 μM) and glycine (50 μM), as compared to NMDA response in the presence of CGX-1007 (3 μM). C: Plots of the concentration-response of CGX-1007 (0.001-10 μM) on NMDA-gated currents from cells transfected with NR1a/NR2A and NR1a/NR2B receptors. CGX-1007 inhibited the currents from both NR1a/NR2A and NR1a/NR2B containing receptors (p < 0.05, two-way ANOVA). D: NMDA-gated currents obtained from the cells expressing NR1a/NR2A and NR1a/NR2B receptors were completely inhibited by APV (100 μM).