Table 1.
Characteristics of 2296 women with abnormal cytology.
| Characteristics at time of first abnormal Pap unless otherwise indicated |
% (N) |
p-value HIV+ vs. HIV− |
||
|---|---|---|---|---|
| Overall | HIV-negative | HIV-positive | ||
|
| ||||
| N=2296 | N=472 | N=1824 | ||
|
| ||||
| Age in years: median [IQR] | 36 [30, 42] | 33 [26, 40] | 37 [31, 42] | <0.001 |
| Race, %(n) | 0.70 | |||
| White, Non-Hispanic | 14% (324) | 13% (60) | 14% (264) | |
| White, Hispanic | 8% (184) | 9% (41) | 8% (143) | |
| Black, Non-Hispanic | 56% (1286) | 57% (267) | 56% (1019) | |
| Black, Hispanic | 3% (59) | 3% (16) | 2% (43) | |
| Other Race | 19% (442) | 19% (88) | 19% (354) | |
| Smoking Status | 0.88 | |||
| Current | 51% (1178) | 52% (246) | 51% (932) | |
| Former | 17% (387) | 16% (76) | 17% (311) | |
| Education at baseline | 0.58 | |||
| < high school | 38% (866) | 36% (169) | 38% (697) | |
| high school | 31% (701) | 31% (145) | 31% (556) | |
| > high school | 32%(722) | 33% (156) | 31% (566) | |
| Cumulative number of sexual partners at study baseline |
0.007 | |||
| 0-4 | 38% (869) | 32% (151) | 40% (718) | |
| 5-10 | 28% (634) | 29% (136) | 27% (498) | |
| 11-100 | 27% (613) | 32% (151) | 25% (462) | |
| >100 | 7% (171) | 7% (33) | 8% (138) | |
| Number of sexual partners in 6 months prior to 1st abnormal Pap |
<0.001 | |||
| none | 22% (499) | 11% (51) | 25% (448) | |
| 1-2 | 70% (1603) | 75% (353) | 69% (1250) | |
| >2 | 8% (182) | 14% (68) | 6% (114) | |
| 1st abnormal PAP result | <0.001 | |||
| ASCUS | 75% (1718) | 88% (413) | 72% (1305) | |
| LSIL | 23% (526) | 11% (51) | 26% (475) | |
| HSIL | 2% (52) | 2% (8) | 2% (44) | |
| Colposcopy at any time after abnormal Pap |
85% (1947) | 80% (376) | 86% (1571) | <0.001 |
| CIN3 or worse in follow-up | 8% (163/1947) | 6% (22/376) | 9% (141/1571) | |
| CIN2 or worse in follow-up | 19%(371/1947) | 11% (42/376) | 21%(329/1571) | |
| Among HIV-positive only: | ||||
| CD4 cell count: median [IQR] | 349 [199, 526] | |||
| HIV viral RNA load, copies/mL | 8900 | |||
| : median [IQR] | [360,56000] | |||
| Post HAART initiation | 36% (659) | |||
| Ever AIDS | 31% (562) | |||
Missing data: race, n=1; smoking status, n=1; education, n=7; sexual partners at baseline, n=9; sexual partners in last six months, n=12; CD4, n=49; HIV viral RNA load, n=50.
At time of first abnormal Pap unless otherwise indicated. Numbers in each category may not sum to column total because of missing data.
By chi-square test for independence for categorical variables and Wilcoxon Rank Sum test for continuous variables.
Continuous variables are presented as median [interquartile range], categorical variables as n (%)
Among HIV seropositive women only.
Highly active antiretroviral therapy
Atypical squamous cells of undetermined significance
Low grade squamous intraepithelial lesion
High grade squamous intraepithelial lesion
Cervical intraepithelial neoplasia grade 3 or adenocarcinoma in situ or invasive cancer
CIN3 or worse or CIN2