Table 3.
Risk factors for CIN2 or worse and CIN3 or worse among 1459 HIV seropositive and 360 HIV seronegative women with ASCUS or LSIL Pap results and available covariate data.
| Characteristics at time of first | CIN3 or worse | CIN2 or worse |
|---|---|---|
| abnormal Pap | N=1819 | N=1819 |
|
| ||
| Events=133 | Events=328 | |
| HR (95% CI) | HR (95% CI) | |
|
| ||
| HIV negative | 1.00 | 1.00 |
| HIV positive | 1.33 (0.79, 2.34) | 1.66 (1.15, 2.45) |
| CD4 cells/cmma | ||
| <200 | 1.34 (0.84, 2.08) | 1.30 (0.97, 1.73) |
| 200-350 | 0.81 (0.50, 1.27) | 1.05 (0.79, 1.38) |
| ≥350 | 1.00 | 1.00 |
| Ever AIDSb | 0.80 (0.51, 1.22) | 0.84 (0.64, 1.10) |
| First abnormal Pap result | ||
| ASCUSc | 1.00 | 1.00 |
| LSILd | 1.18 (0.79, 1.74) | 1.81 (1.43, 2.28) |
| Age, per 5 years | 1.00 (0.89, 1.12) | 0.92 (0.85, 0.98) |
| Smoking Status | ||
| Never | 1.00 | 1.00 |
| Current | 1.57 (1.04, 2.43) | 1.45 (1.12, 1.90) |
| Former | 1.02 (0.54, 1.86) | 1.07 (0.73, 1.54) |
| Education at study baseline | ||
| > high school | 1.00 | 1.00 |
| ≤ high school | 1.34 (0.90, 2.06) | 1.38 (1.07, 1.81) |
a
Among HIV seropositive women only
b
Acquired immunodeficiency syndrome
c
Atypical squamous cells of undetermined significance
d
Low grade squamous intraepithelial lesion