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. Author manuscript; available in PMC: 2015 Mar 1.
Published in final edited form as: Clin Cancer Res. 2013 Dec 5;20(5):1104–1113. doi: 10.1158/1078-0432.CCR-13-1573

Table 1.

Potency of a panel of NSAIDs to inhibit colon tumor cell growth and cyclooxygenases.

NSAID Growth IC501
(µmol/L)		 COX-1 IC502
(µmol/L)		 COX-2 IC502
(µmol/L)		 Serum levels
(µmol/L)3
Celecoxib 50 >30 2.25 2
Sulindac sulfide 60 1.02 10.4 15
Diclofenac 160 0.14 0.05 6
Indomethacin 180 0.16 0.46 1.4
Piroxicam 900 0.76 8.9 17
Ibuprofen 975 4.75 >30 40
Flurbiprofen 1800 0.44 6.42 53
Aspirin 5000 4.5 13.9 10
1

HT-29 human colon tumor cells, 72 h MTS assay (106).

2

Whole blood COX assays (107).

3

From therapeutic dosages (108). Table reproduced from Gurpinar et al., Frontiers in Oncology, 2013 (106).